Acts 13:2-4

While they were serving the Lord and fasting, the Holy Spirit said, “Set apart for Me Barnabas and Saul (Paul) for the work to which I have called them.” Then after fasting and praying, they laid their hands on them [in approval and dedication] and sent them away [on their first journey]. So then, being sent out by the Holy Spirit, they went down to Seleucia, and from there they sailed to Cyprus.