Romans 1:18, 21

For God in heaven unveils his holy anger breaking forth against every form of sin, both toward ungodliness that lives in hearts and evil actions. For the wickedness of humanity deliberately smothers the truth and keeps people from acknowledging the truth about God.

Throughout human history the fingerprints of God were upon them, yet they refused to honor him as God or even be thankful for his kindness. Instead, they entertained corrupt and foolish thoughts about what God was like. This left them with nothing but misguided hearts, steeped in moral darkness.