Romans 9:10-13

And that’s not the only time. To Rebecca, also, a promise was made that took priority over genetics. When she became pregnant by our one-of-a-kind ancestor, Isaac, and her babies were still innocent in the womb—incapable of good or bad—she received a special assurance from God. What God did in this case made it perfectly plain that his purpose is not a hit-or-miss thing dependent on what we do or don’t do, but a sure thing determined by his decision, flowing steadily from his initiative. God told Rebecca, “The firstborn of your twins will take second place.” Later that was turned into a stark epigram: “I loved Jacob; I hated Esau.”