"According to an old tradition, respected women of Jerusalem provided a narcotic drink to those condemned to death in order to decrease their sensitivity to the excruciating pain . . . . When Jesus arrived at Golgotha he was offered . . . wine mixed with myrrh, but he refused it, choosing to endure with full consciousness the sufferings appointed for him (The Gospel of Mark, p. 564)"
“So the first wine (mixed with myrrh) was designed to dull Jesus’ pain, to keep him from having to endure the cross with full consciousness. This wine he refused.”
“A sour wine vinegar is mentioned in the OT as a refreshing drink (Numbers 6:13; Ruth 2:14), and in Greek and Roman literature as well it is a common beverage appreciated by laborers and soldiers because it relieved thirst more effectively than water and was inexpensive . . . . There are no examples of its use as a hostile gesture. The thought, then, is not of a corrosive vinegar offered as a cruel jest, but of a sour wine of the people. While the words “let us see if Elijah will come” express a doubtful expectation, the offer of the sip of wine was intended to keep Jesus conscious for as long as possible” (Ibid., 573–574).”
“And the second (sour) wine was given to keep him “conscious for as long as possible,” and thus have the effect of prolonging his pain. This is the wine Jesus drank.”
*John Piper